Application

This product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact [email protected].

Research CategoryNeuroscience

Cell Line Description

Cancer Cells

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

HOG is a clonal cell line derived from a surgically removed human oligodendroglioma (HOG) . HOG cells express oligodendrocyte markers including low levels of the 15-kDa form of myelin basic protein (MBP) and high levels of CNPase protein. HOG cells do not express GFAP, a astrocyte marker and were found to have minimal levels of glutamine synthetase activity . HOG cells express neurotransmitter receptors such as A2-adenosine, prostaglandin E1 (PGE1) and beta2-adrenergic receptores (beta-ARs) that activate the adenylate cylase signaling pathway . HOG cells also express muscarinic and histamine receptors that are linked to inositol phosphate signaling pathways .

Quality

Each vial contains ≥ 1X106 viable cells.
Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, C, and HIV-1 & 2 viruses as assessed by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
Cells are negative for mycoplasma contamination.
Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.

Storage and Stability

Store in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.