General description

Tumor necrosis factor alpha (TNF-α), is the prototypic ligand of the TNF superfamily. It is a pleiotropic molecule that plays a central role in inflammation, apoptosis, and immune system development. TNF-α is produced by a wide variety of immune and epithelial cell types. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes.

Legal Information

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Physical form

HumanKine TNF alpha is manufactured using all non-animal reagents and is considered Xeno-Free

Quality

Bioactivity assay: Determined by the dose-dependent cytotoxity of the TNF alpha sensitive cell line L-929 in the presence of
Actinomycin D. Typically ﹤0.9 ng/mL ED50.