Application

Research CategoryStem Cell Research

Research Sub CategoryGrowth Factors & Receptors

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Product Source: E. coli

Bone morphogentic protein 4 (BMP4) is a TGFβ superfamily ligand that is widely expressed from early embryogenesis through adulthood. It plays an important role in mesenchyme formation, epidermal determination, suppression of neural induction, the development of multiple organs, and tissue repair. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva.Animal free human recombinant BMP4 is a fully active homodimeric protein consisting of two 107 amino acid subunits which correspond to amino acids 303-408 of the full length BMP-4 precursor.

Physical form

Recombinant animal free human BMP-4 is manufactured using all non-animal reagents

Product is filtered through a 0.2 micron filter before lyophilization.

Quality

Bioactivity assay: Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-10 ng/ml.

Specificity

Cross ReactivtyMouse

Storage and Stability

Store at -20°C for up to 6 months from date of receipt.