Analysis Note

ControlRat liver tissue lysate

Application

Research Sub CategoryTranscription Factors

Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Dermo-1 in rat liver tissue.

Research CategoryStem Cell Research

Anti-Dermo-1 Antibody is an antibody against Dermo-1 for use in WB, IH(P).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

General description

Dermo-1, also known as Twist-related protein 2, is a basic helix-loop-helix transcription factor that has been shown to be a negative regulator for gene transcription and apoptosis. Basic helix-loop-helix transcription factors are implicated in cell lineage determination and differentiation. Dermo-1 shares extensive homology with another basic helix-loop-helix transcription factor, Twist. Studies suggest that Dermo-1 may inhibit osteoblast maturation during osteoblast development and maintain cells in preosteoblast phenotype.

Immunogen

KLH-conjugated linear peptide corresponding to human Dermo-1.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Affinity purified

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Quality

Evaluated by Western Blot in rat liver tissue lysate.

Western Blot Analysis: 0.05 µg/mL of this antibody detected Dermo-1 on 10 µg of rat liver tissue lysate.

Storage and Stability

Stable for 1 year at 2-8°C from date of receipt.

Target description

~18 kDa observed