Biochem/physiol Actions
LDN-27219 is a thieno[2,3-d]pyrimidine-4-one-acylhydrazide derivative. Closed conformation of TG2 induced by LDN-27219 can be a potential therapeutic strategy for age-related vascular dysfunction and lowering blood pressure.
LDN-27219 is a revesible inhibitor of transglutaminase 2 (TG2) that binds to the GTP binidng site of the enzyme and inhbits activity with and IC50 of 600 nM.
Packaging
5, 25 mg in glass bottle
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