Application

Immunofluorescence Analysis: A representative lot was used by an independent laboratory in IF. (de Planell-Saguer, M., et al. (2009). Hum Mol Genet. 18(12):2115-2126.)

Immunoprecipitation Analysis: A representative lot was used by an independent laboratory in IP. (de Planell-Saguer, M., et al. (2009). Hum Mol Genet. 18(12):2115-2126.)

Anti-IGHMBP2 Antibody, clone11-24 is a Mouse Monoclonal Antibody for detection of IGHMBP2 also known as immunoglobulin mu binding protein 2, DNA-binding protein SMUBP-2 & has been validated in WB, ICC & IP.

General description

Immunoglobulin mu-binding protein 2 (IGHMBP2) is a nucleic acid binding protein that acts on both RNA and DNA. The mature protein contains an ATP-dependent RNA/DNA helicase domain, an R3H single-stranded nucleic acid-binding domain, and a zinc finger domain. Consistent with these multiple functional domains, in vitro data suggests this protein is involved in and array of cellular functions such as transcriptional activation, DNA replications immunoglobulin class switching, pre-mRNA splicing, and translation.

Immunogen

Recombinant Protein corresponding to human IGHMBP2.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Physical form

Format: Purified

Quality

Evaluated by Western Blot in Hek293 cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected IGHMBP2 on 10 µg of Hek293 cell lysate.

Target description

~110 kDa observed. Band observed at ~60 kDa may be a proteolytic fragment of IGHMBP2. (de Planell-Saguer, M., et al. (2009). Hum Mol Genet. 18(12):2115-2126.)