Biochem/physiol Actions

Cell permeable: no

Reversible: yes

Product does not compete with ATP.

Primary TargetA potent vasoconstrictor

General description

A potent vasoconstrictor. Reversibly inhibits Ca²⁺-activated K⁺ channels in vascular smooth muscle cells.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Xiong, Z., and Cheung, D.W. 1994. Pflugers Arch. 429, 280.Wahlestedt, C., et al. 1993. Science259, 528.Leibowitz, S.F. 1992. NeuroReport3, 1023.

Packaging

Yes

Sequence

H-Tyr-Pro-Ser-Lys-Pro-Asp-Asn-Pro-Gly-Glu-Asp-Ala-Pro-Ala-Glu-Asp-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-His-Tyr-Ile-Asn-Leu-Ile-Thr-Arg-Gln-Arg-Tyr-NH₂

Warning

Toxicity: Harmful (C)