Biochem/physiol Actions

Reversible: yes

Primary TargetP2X

General description

A metabolically stable and selective P2X purinergic receptor agonist (pEC₅₀ = 5.81) that is shown to be more potent than ATP. Elicits contractions in ileum through the release of endogenous acetylcholine, which can be blocked by tetrodotoxin (~1 mM). Shown to depolarize cells of the longitudinal muscle strips (~ 200 nM to 4 µM) that reaches a peak within 2-3 min after application and then decays to a steady level.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Sawyer, G.W., et al. 2000. Br. J. Pharmacol.129, 1458.Komori, S., et al. 1988. Br. J. Pharmacol.94, 9.

Warning

Toxicity: Standard Handling (A)