Methotrexate hydrate, >=99.0% (sum of enantiomers, HPLC)

Code: 06563-25MG D2-231

Application

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also...


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£74.80 25MG
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Application

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.

Other Notes

Folic acid antagonist. Potent inhibitor of dihydrofolate reductase.

assay≥99.0% (sum of enantiomers, HPLC)
biological sourcesynthetic
formpowder or crystals
Gene Informationhuman ... DHFR(1719)
impurities≤0.1% sulfated ash
InChI keyFPJYMUQSRFJSEW-ZOWNYOTGSA-N
InChI1S/C20H22N8O5.H2O/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30;/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27);1H2/t13-;/m0./s1
mp185-204 °C
optical activity[α]/D +21.0±2.0°
Quality Level200
SMILES string[H]O[H].CN(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O
solubilitywater: insoluble
storage temp.−20°C
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Description
Unit Size
List Price
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06563-100MG
Methotrexate hydrate, >=99.0% (sum of enantiomers, HPLC)

Unit:100MG
List Price: £227.00
Source:List Price
ADD
06563-5MG
Methotrexate hydrate, >=99.0% (sum of enantiomers, HPLC)

Unit:5MG
List Price: £27.00
Source:List Price
ADD
Cas Number133073-73-1
Hazard Class6.1
Un Number1544
Pack Group3
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