Biochem/physiol Actions

Cell permeable: no

Reversible: no

Primary TargetSubstance P receptors

Product does not compete with ATP.

General description

Neuropeptide found in high concentrations in the gut. When released from afferent nerves, causes a neurogenic inflammatory response, including mast cell degranulation. Induces Ca²⁺ mobilization. Reported to activate G_oα, G_q/11α, and G_sα subunits in CHO cells via activation of substance P receptors. Also reported to induce superoxide production in neutrophils.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Other Notes

Roush, E.D., and Kwatra, M.M. 1998. FEBS Lett. 428, 291.Chiwakata, C.B., et al. 1996. Infect. Immun. 64, 5106.Tanabe, T., et al. 1996. Eur. J. Pharmacol. 299, 187.Heath, M.J., et al. 1994. J. Neurophysiol. 72, 1192.Zhu, J., et al. 1994. Eur. J. Pharmacol. 268, 279.Garland, A.M., et al. 1993. Soc. Neurosci. 19, Abstract 104.6.Wei, J.Y., et al. 1993. Soc. Neurosci. 19, Abstract 136.14.

Packaging

Yes

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Sequence

H-Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH₂

Warning

Toxicity: Standard Handling (A)